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Original Research Article | OPEN ACCESS

Yizhi decoction as a therapy for vascular dementia: A meta-analysis

Zhengjun Xin1, Sheng Li2

1College of Pharmacy; 2College of Management, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

For correspondence:-  Sheng Li   Email: soonl@sina.com   Tel:+9612861800237

Accepted: 23 November 2018        Published: 27 December 2018

Citation: Xin Z, Li S. Yizhi decoction as a therapy for vascular dementia: A meta-analysis. Trop J Pharm Res 2018; 17(12):2497-2506 doi: 10.4314/tjpr.v17i12.28

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: Vascular dementia (VD) constitutes a heavy burden in health care systems in ageing societies. This review was aimed at assessing the effectiveness of Yizhi decoction against VD.
Methods: Five computerized databases were searched. A total of 262 publications were retrieved. Jadad evaluation was used to analyze the quality of the literature. Random methods, random allocation concealment and blinding, withdrawal, exiting and other aspects were included. RevMan 5.3 was used for meta-analysis.
Results: There were 1045 patients, consisting of 527 cases in the treatment group (Yizhi decoction group) and 518 cases in the control group. Risk ratio revealed that Yizhi decoction was significantly effective against VD, while the weighted by mean difference demonstrated that Yizhi decoction improved the MMSE score of patients.
Conclusion: Yizhi decoction improves the quality of daily life and mental state in VD patients. However, more rigorous and scientific case studies are still needed for further confirmation to strengthen and support these findings.

Keywords: Vascular dementia, Yizhi decoction, Meta-analysis

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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